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College football odds Week 1: How to bet Illinois-Indiana

Illinois will travel to Big Ten foe, Indiana, to kick off the first full week of the college football season. 

The Fighting Illini are coming off a 5-7 record in 2021, where they failed to make it to a bowl game, yet defeated No. 7 Penn State in a thrilling nine-overtime slugfest in the middle of the season. 

Indiana is coming off a subpar season, where they finished 2-10, losing eight-straight games to end their regular season.

Here’s everything you need from a betting perspective on Friday afternoon’s Illinois-Indiana game, from the point spread, moneyline, total over/under and expert pick (odds via FOX Bet).

RELATED: Top plays from Week 0

Illinois @ Indiana (8 p.m. ET Friday, FS1)

Point spread: Indiana -2 (Indiana is favored to win by more than 2 points, otherwise Illinois covers)
Moneyline: Indiana -125 to win (bet $10 to win $18 total); Illinois +105 underdog to win (bet $10 to win $20.50 total)
Total scoring over/under: 45.5 points scored by both teams combined

Illinois Fighting Illini


Indiana Hoosiers


Pick via FOX Sports Betting Analyst Sam Panayotovich:

“I wouldn’t put much stock into Illinois pouring five touchdowns on Wyoming last Saturday,” he explained. “Indiana’s defense is worlds ahead of Wyoming’s and the battle of these two bordering states is shaping up to be the first to 20 points.

“Indiana returns seven players on the defensive side of the ball and head coach Tom Allen will undoubtedly have his squad prepared for Illinois quarterback Tommy DeVito,” he continued.  “The Illini will be a mostly run-first team in Big Ten play, which is exactly the type of team that Indiana thrives against.

“The “Under” 45.5 is definitely worth a look.” 

PICK:  Under 45.5 points scored by both teams combined

Are you ready for some college football? If so, head over to FOX Bet for all your wagers.


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