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NFL odds Week 1: Opening lines for every game, picks

Are you ready for some football? We’re a few days from the season starting!

Here is everything you need to know about the NFL odds for Week 1 — the point spread, moneyline, total over/under for every game and picks by FOX Sports betting analyst Jason McIntyre (with all NFL odds via FOX Bet)

Can Dak Prescott lead this year’s Cowboys to a Super Bowl? | UNDISPUTED

The Dallas Cowboys have sky-high expectations but according to Jean-Jacques Taylor of the Dallas Morning News, it all comes down to Dak Prescott.

For more, from gambling-friendly schedules featuring live, updating odds to expert analysis and the day’s most-bet games, check out the all-new “NFL Odds” section on the FOX Sports App and FOXSports.com!

The defending Super Bowl champion Los Angeles Rams and 2021 Offensive Player of the Year, wide receiver Cooper Kupp, open the season by playing host to quarterback Josh Allen and the Buffalo Bills.

Tom Brady and the Tampa Bay Buccaneers wrap up the slate of games Sunday, Sept. 11 by playing at the Dallas Cowboys.

Week 1 wraps up with the Denver Broncos and new quarterback Russell Wilson traveling to Seattle to take on Wilson’s former team the Seahawks on Monday Night Football on Sept. 12.

Week 1 got a lot juicier with the Cleveland Browns trading quarterback Baker Mayfield, the No. 1 pick in 2018, to the Carolina Panthers.

Guess who plays each other opening week in Charlotte, N.C.?

Here are the updated lines posted for opening week (via FOX Bet):

WEEK 1 GAMES *

Buffalo Bills @ Los Angeles Rams (8:20 p.m. ET Sept. 8, NBC)

Point spread: Bills -2.5 (Bills favored to win by more than 2.5 points, otherwise Rams cover)
Moneyline: Bills -138 favorites to win (bet $10 to win $17.71 total); Rams +115 underdogs to win (bet $10 to win $21.50 total)
Total scoring over/under: 52.5 points scored by both teams combined

New Orleans Saints @ Atlanta Falcons (1 p.m. ET Sept. 11, FOX)

Point spread: Saints -5.5 (Saints favored to win by more than 5.5 points, otherwise Falcons cover)
Moneyline: No line available
Total scoring over/under: 42.5 points scored by both teams combined

San Francisco 49ers @ Chicago Bears (1 p.m. ET Sept. 11, FOX)

Point spread: 49ers -6.5 (49ers favored to win by more than 6.5 points, otherwise Bears cover)
Moneyline: 49ers -333 favorites to win (bet $10 to win $13 total); Bears +260 underdogs to win (bet $10 to win $36 total)
Total scoring over/under: 41.5 points scored by both teams combined

Pittsburgh Steelers @ Cincinnati Bengals (1 p.m. ET Sept. 11, FOX)

Point spread: Bengals -6.5 (Bengals favored to win by more than 6.5 points, otherwise Steelers cover)
Moneyline: Bengals -278 favorites to win (bet $10 to win $13.60 total); Steelers +220 underdogs to win (bet $10 to win $32 total)
Total scoring over/under: 44.5 points scored by both teams combined

FOX Bet’s Jason McIntyre: “Mike Tomlin as an underdog in a division game? Take my money. The Bengals will be the most overvalued team in the market next season. Yes, they have an elite QB/WR combo in Joe Burrow and Ja’Marr Chase, but let’s also remember this team faced the third-easiest schedule in the NFL last season.

“The Bengals will now face the seventh-most difficult schedule when looking at the opponent’s season win totals. Bengals fans can earmuff the rest; everyone else, listen closely. Cincinnati held on to beat the Raiders when they failed inside the 10-yard line on fourth down. The Bengals beat the Titans on a walk-off field goal and then beat the Chiefs in overtime despite KC getting the ball first. If they don’t win all three of those games, Pittsburgh is probably closer to +3 or +3.5.

“This line is inflated. Give me the extra points.”

PICK: Steelers (+6.5) to lose by fewer than 6.5 points (or win outright)

Philadelphia Eagles @ Detroit Lions (1 p.m. ET Sept. 11, FOX)

Point spread: Eagles -4 (Eagles favored to win by more than 4 points, otherwise Lions cover)
Moneyline: Eagles -200 favorites to win (bet $10 to win $15 total); Lions +165 underdogs to win (bet $10 to win $26.50 total)
Total scoring over/under: 48.5 points scored by both teams combined

New England Patriots @ Miami Dolphins (1 p.m. ET Sept. 11, CBS)

Point spread: Dolphins -3 (Dolphins favored to win by more than 3 points, otherwise Patriots cover)
Moneyline: Dolphins -162 favorites to win (bet $10 to win $16.17 total); Patriots +135 underdogs to win (bet $10 to win $23.50 total)
Total scoring over/under: 47 points scored by both teams combined

Baltimore Ravens @ New York Jets (1 p.m. ET Sept. 11, CBS)

Point spread: Ravens -7 (Ravens favored to win by more than 7 points, otherwise Jets cover)
Moneyline: Ravens -303 favorites to win (bet $10 to win $13.30 total); Jets +250 underdogs to win (bet $10 to win $35 total)
Total scoring over/under: 44.5 points scored by both teams combined

Jacksonville Jaguars @ Washington Commanders (1 p.m. ET Sept. 11, CBS)

Point spread: Commanders -3 (Commanders favored to win by more than 3 points, otherwise Jaguars cover)
Moneyline: Commanders -167 favorites to win (bet $10 to win $15.99 total); Jaguars +140 underdogs to win (bet $10 to win $24 total)
Total scoring over/under: 44 points scored by both teams combined

Cleveland Browns @ Carolina Panthers (1 p.m. ET Sept. 11, CBS)

Point spread: Panthers -2.5 (Panthers favored to win by more than 2.5 points, otherwise Browns cover)
Moneyline: Panthers -143 favorites to win (bet $10 to win $16.99 total); Browns +120 underdogs to win (bet $10 to win $22 total)
Total scoring over/under: 42 points scored by both teams combined

Indianapolis Colts @ Houston Texans (1 p.m. ET Sept. 11, CBS)

Point spread: Colts -8 (Colts favored to win by more than 8 points, otherwise Texans cover)
Moneyline: Colts -400 favorites to win (bet $10 to win $12.50 total); Texans +300 underdogs to win (bet $10 to win $40 total)
Total scoring over/under: 45.5 points scored by both teams combined

New York Giants @ Tennessee Titans (4:25 p.m. ET Sept. 11, FOX)

Point spread: Titans -6 (Titans favored to win by more than 6 points, otherwise Giants cover)
Moneyline: Titans -278 favorites to win (bet $10 to win $13.60 total); Giants +200 underdogs to win (bet $10 to win $30 total)
Total scoring over/under: 44 points scored by both teams combined

McIntyre: “I’m not a trend bettor, but one worth looking at in Week 1: Teams that didn’t make the playoffs last season against teams that did. Like it or not, the prior year’s playoff team tends to be overvalued in the market.

“When it comes to this matchup, the Titans were the No. 1 seed in the AFC last year. On the flip side, the Giants were one of the league’s biggest dumpster fires, and they fired their coach.

“I like New York’s new coach, Brian Daboll, and think he will be a tremendous value add to struggling QB Daniel Jones. The Giants will be undervalued with a full arsenal of healthy weapons — like Saquon Barkley and Kenny Golladay — in September.

“Getting nearly a touchdown in this spot is too good to pass up.”

PICK: Giants (+6.5 at FOX Bet at time of pick) to lose by fewer than 6.5 points (or win outright)

Green Bay Packers @ Minnesota Vikings (4:25 p.m. ET Sept. 11, FOX)

Point spread: Packers -2 (Packers favored to win by more than 2 points, otherwise Vikings cover)
Moneyline: Packers -133 favorites to win (bet $10 to win $17.52 total); Vikings +110 underdogs to win (bet $10 to win $21 total)
Total scoring over/under: 48 points scored by both teams combined

Kansas City Chiefs @ Arizona Cardinals (4:25 p.m. ET Sept. 11, CBS)

Point spread: Chiefs -4.5 (Chiefs favored to win by more than 4.5 points, otherwise Cardinals cover)
Moneyline: Chiefs -200 favorites to win (bet $10 to win $15 total); Cardinals +165 underdogs to win (bet $10 to win $26.50 total)
Total scoring over/under: 53.5 points scored by both teams combined

Las Vegas Raiders @ Los Angeles Chargers (4:25 p.m. ET Sept. 11, CBS)

Point spread: Chargers -3.5 (Chargers favored to win by more than 3.5 points, otherwise Raiders cover)
Moneyline: Chargers -182 favorites to win (bet $10 to win $15.49 total); Raiders +150 underdogs to win (bet $10 to win $25 total)
Total scoring over/under: 52.5 points scored by both teams combined

Tampa Bay Buccaneers @ Dallas Cowboys (8:20 p.m. ET Sept. 11, NBC)

Point spread: Buccaneers -1.5 (Buccaneers favored to win by more than 1.5 points, otherwise Cowboys cover)
Moneyline: Buccaneers -125 favorites to win (bet $10 to win $18 total); Cowboys +105 underdogs to win (bet $10 to win $20.50 total)
Total scoring over/under: 50 points scored by both teams combined

Denver Broncos @ Seattle Seahawks (8:15 p.m. ET Sept. 12, ABC/ESPN)

Point spread: Broncos -6 (Broncos favored to win by more than 6 points, otherwise Seahawks cover)
Moneyline: Broncos -250 favorites to win (bet $10 to win $14 total); Seahawks +205 underdogs to win (bet $10 to win $30.50 total)
Total scoring over/under: 42 points scored by both teams combined

* odds updated as of 9/3/2022

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