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Nirvana Existence Sciences (CSE:NIRV) Investor Evaluation


Evaluation

Opioids lend a hand folks to find aid from ache, whether or not brought about by way of surgical operation or from a protracted situation, however they’ve the prospective to be abused or result in bad illicit medication. This has created a disaster that has an important affect on our international society. A 2015 file from the White Area Council of Financial Advisers estimated that the opioid disaster value the U.S. economic system over US$500 billion. The disaster has gotten worse. A up to date 500-page congressional file estimated that opioid-related deaths now value US$1 trillion yearly, more or less 4.3 p.c of the rustic’s GDP. A complementary file from the U.S. Middle for Illness Prevention (CDC) comprises nonfatal accidents and estimates the value to be US$4.2 trillion. Having a look past the USA, the International Well being Group estimates that 500,000 folks die in keeping with 12 months because of drug overdose, and 70 p.c of the ones deaths are brought about by way of opioids.

What may also be finished to battle the opioid disaster? It’s a posh downside, with governments, researchers, and docs all seeking to uncover the answer. Remedy is one solution to combatting this disaster, preferably serving to opioid addicts go back to a existence that’s loose from drug abuse. But remedy for opioid dependancy usually is composed of cleansing, psychotherapy and changing the issue opioid with a weaker opioid, equivalent to methadone or buprenorphine. Whilst this routine would possibly lend a hand some customers get better, one learn about discovered that 91 p.c of addicts will relapse after remedy. We’d like simpler remedy to in point of fact battle the disaster.

Psychedelics have emerged as a promising remedy for opioid dependancy, along side appearing possible for treating alcohol use dysfunction or even melancholy. Ketamine, identified for its function in anesthesia, is also an efficient remedy for alcohol use dysfunction. Psilocybin, the lively element in psychedelic mushrooms, displays promise for treating melancholy. Ibogaine, which is located essentially within the roots of the Iboga plant, would possibly lend a hand opioid addicts get better from their dependancy and supply a non-opioid substitute for ache aid. Alternatively, every psychedelic wishes additional analysis and construction to grow to be a in point of fact healing drugs that may be legally utilized in remedy.

Nirvana Existence Sciences (CSE:NIRV) used to be based to expand novel healing merchandise derived from psychedelics. The corporate believes that naturally sourced psychedelics utilized in distinctive formulations can ship non-addictive answers that help in opioid dependancy remedy and ongoing ache control. Nirvana Existence Sciences is concentrated strictly on creating efficient merchandise, somewhat than providing wellness retreats or clinics like a few of their competition.

Nirvana Life Sciences

The corporate has centered two merchandise for its first construction segment. One product will focal point on transitioning from opioids to non-addictive ache aid treatments and preferably prevents relapse. The second one product will supply non-addictive ache aid. Nirvana Existence Sciences started by way of obtaining the highbrow assets (IP) in the back of those formulations and has since carried out its personal analysis to advance them.

How is the corporate doing this legally? The usage of psychedelics in usual medicinal treatments is a brand new frontier, and as such, Nirvana Existence Sciences is taking each and every precaution in opposition to criminal issues or even taking into consideration the passion criminals can have in its amenities. It has won a Segment 56 Exemption from Well being Canada, enabling them to legally habits its analysis and construction in Vancouver. Moreover, its new facility might be constructed to Degree 9 Safety Requirements to safeguard its analysis. The corporate may be pursuing a Broker’s License from Well being Canada to permit for the motion of fabrics between licensees. The top objective is to introduce FDA-approved drugs for well-liked utilization.

Pre-clinical analysis for its formulations have already begun. This analysis is being undertaken on the College of Camerino in Italy. This lab used to be granted particular permission from the Italian executive to paintings with psilocybin-based compounds. Experiences from those trials are anticipated in Q3 2022.

Nirvana Existence Sciences is led by way of visionaries and docs running in combination to completely expand those probably modern drugs. Bruce Clark, CEO, is motivated by way of discovering new answers to complicated societal problems and has 30 years of revel in managing cutting edge agencies. Dr. Sazzad Hossain, CSO, has served on main Canadian bio pharmaceutical agencies and is regarded as a drug discovery chief. Robert August, head of innovation, is an academically skilled chemist who’s revered within the psychedelic neighborhood and is a sturdy suggest for finishing prohibition.

Michael McCune, Vice President of Operations, has years of revel in within the extraction area.. Connie Grasp, CFO, has over twenty years of revel in in accounting and control, together with running with international and home agencies. The corporate has attracted an outstanding crew of researchers together with Dr. Massimo Nabissi and Dr. Naseem Gaur.

Corporate Highlights

  • Nirvana Existence Sciences is an cutting edge analysis and construction corporate interested by novel formulations for opioid dependancy and ache control that use psychedelic compounds.
  • The corporate is solely interested by merchandise, somewhat than wellness retreats or psychotherapy systems like a few of its competition.
  • Nirvana Existence Sciences’ first segment of construction is concentrated on two merchandise, one to assist in opioid dependancy restoration and the opposite is concentrated on non-addictive ache control.
  • IP has been bought from researchers who’ve widely studied the consequences of psychedelic compounds for medicinal functions
  • The corporate is taking each and every precaution to function legally and give protection to in opposition to possible felony parts that can goal its amenities
  • Pre-clinical analysis started in 2021 and the consequences are anticipated in Q3 2022 and can decide long term traits
  • A powerful crew of docs and visionaries lead the corporate, every bringing their strong point to the corporate to completely expand its merchandise

Key Merchandise

Medication for Opioid Addiction

Drugs for Opioid Habit

The corporate has formulated a product that assists within the transition from opioids to non-addictive ache aid. A lot of Nirvana Existence Sciences’ focal point is on creating and refining this product, because it paves the way in which for its 2nd product which will function a standalone product for the ones hooked on opioids to go back to an opioid-free existence.

Mission Highlights:

  • Formulated to Save you Abuse: The lively element can best be launched when taken orally, making IV or insufflation useless because the lively element might not be launched.
  • Prioritizing Herbal Fabrics Over Artificial Replacements: Maximum competition goal to expand artificial psychedelics, while Nirvana Existence Sciences is interested by perfecting a scalable procedure that extracts the specified compounds from herbal resources, equivalent to mushrooms. The corporate would possibly nonetheless use artificial possible choices if required.
  • Unique License to Proprietary Extraction Era: The corporate has secured a license that provides it unique get right of entry to to extraction era that can lend a hand scale the manufacturing of its drugs, referred to as PureAI Distillation.

Drugs for Non-Addictive Ache Control

Many of us who expand opioid dependancy nonetheless want ache control treatments. The corporate’s 2nd product targets to supply ache aid with out developing a brand new dependancy. Psychedelic compounds have inherent ache aid houses which were remoted to be used because the lively element on this product.

Mission Highlights:

  • Simplest Efficient Orally: Similar to the dependancy remedy product, the corporate’s ache control drugs will best be efficient when taken orally.
  • Artificial Extraction Would possibly End up Viable: The gotten smaller analysis facility in New Delhi has undertaken a singular procedure for generating artificial psilocybin fabrics at scale.
  • Lately Present process Preclinical Analysis: The corporate’s formulations are present process pre-clinical analysis with effects anticipated in Q3 2022.

Control Group

Bruce Clark – Leader Govt Officer

Bruce Clark leads the Nirvana crew, in the hunt for new answers to one in every of our society’s maximum confounding problems. He sees nice possible within the alternatives for the improvement of latest approaches to a posh downside this is each a public well being and financial factor for our communities. Clark is a confirmed innovator who brings 30 years of control revel in throughout quite a lot of industries, together with power, meals and beverage production and existence science. He possesses vast revel in in product construction, production and product distribution and a transparent working out of the regulatory procedure. He has a deep working out of the general public coverage problems at play and the significance of collaboration with all ranges of presidency and well being execs during the construction procedure.

Connie Grasp – Leader Monetary Officer

Connie Grasp has over twenty years of finance, accounting, and control revel in in quite a lot of industries, together with power, mining, and well being science. Previously 12 years, Grasp has acted as an consultant, officer and director for quite a lot of private and non-private agencies, which come with Canadian-based agencies to foreign-controlled entities. From 1999 to 2009, Grasp labored in skilled accounting companies and held senior positions in tax and audit practices. Having served over 40 public- and private-companies, she has received in-depth wisdom of monetary and regulatory affairs. Grasp’s revel in in coping with folks from other cultures and disciplines has solidified her talent to grasp the desires of stakeholders and keep up a correspondence complicated concepts. Grasp is a Member of the Chartered Skilled Accountants of Canada and British Columbia and holds a bachelor of accounting science from the College of Calgary.

Dr. Sazzad Hossain – Leader Clinical Officer

Dr. Sazzad Hossain is the previous leader medical officer of InMed Prescription drugs, a number one public Canadian biopharmaceutical corporate. Up to now he labored as a senior scientist on the Biotechnology Analysis Institute of Nationwide Analysis Council Canada. Dr. Hossain is a drug discovery chief with over 15 years of biotech and pharmaceutical revel in with small molecules and biologics in a couple of illness indications. He has revel in in sped up drug discovery and commercialization processes with blended revel in in preclinical in vivo pharmacology, drug metabolism and pharmacokinetics (DMPK), protection and toxicology. He has led groups within the strategic design of latest herbal well being merchandise and generated masses of hundreds of thousands of bucks in earnings by way of main the improvement of a couple of a hit compounds. Dr. Hossain holds a PhD in biology and used to be a postdoctoral fellow on the Centre for Molecular Medications and Therapeutics on the College of BC.

Robert August – Head of Innovation

Robert August holds a grasp’s of science stage and is an academically skilled medicinal chemist with a focal point on ergolines, phenethylamines and tryptamines. August started his instructional profession at Loyola College in Baltimore, Maryland. Throughout his undergraduate years, he labored as an analytical chemist for Martel Laboratories the place he won his state analytical certifications for greater intracranial drive (ICP), fuel chromatography–mass spectrometry (GCMS) and liquid chromatography with tandem mass spectrometry (LCMS) operations.

Whilst pursuing a postgraduate stage in medicinal chemistry at Johns Hopkins College, he became his focal point towards the synthesis of psychoactive and psychedelic compounds, particularly ergolines equivalent to LSD and phenethylamines like MDMA and 2CB. Round this time, August started to paintings as a analysis chemist; and, in the end, started to actively pursue running partnerships with different chemists who have been researching psychedelic compounds like Dr. David E. Nichols and Nick Sand, with whom August labored in brief in Vancouver, BC. After incomes a name as a talented chemist, he used to be invited to paintings along Ben Alkire at Purdue College in Lafayette, Indiana, the place he went directly to cofound Berkeley-Clearlight Analysis (BCRG). Whilst forming BCRG, August won limitless get right of entry to to the D.E. Nichols Archive at Purdue College and the huge array of synthesis notes created by way of Dr. Oberlender throughout his time as a chemist for the Nichols’ crew. Within the years that adopted, August synthesized a large number of novel compounds and analysis chemical compounds, changing into the primary individual to synthesize 3,4-MDMA Monohydrate HCl as a crystalline forged and as a beta ketone. August is a extremely revered member of the psychedelic neighborhood and an suggest for finishing prohibition.

Michael McCune – Vice President Operations

Michael McCune is a seasoned entrepreneur and innovator within the extraction area. Since 2013, he has implemented his pastime for science to creating novel processes for generating lively pharmaceutical components (API) for the hashish trade. He has constructed a strong point for at-scale extraction of all kinds of fabrics. McCune led the improvement of a modern distillation device that gives vital operational benefits and automation. He has overseen the improvement, trials and contract manufacture of the program. McCune is known as a pace-setter in those applied sciences and has co-authored a number of patents. He maintains an international community and has introduced at a large number of meetings at the subjects of extraction and hashish applied sciences.





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